Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia.

نویسندگان

  • Annick A J M van de Ven
  • Jan Willem Douma
  • Carin Rademaker
  • Anton M van Loon
  • Annemarie M J Wensing
  • Jaap-Jan Boelens
  • Elisabeth A M Sanders
  • Joris M van Montfrans
چکیده

A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immunocompromised host.

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عنوان ژورنال:
  • Antiviral therapy

دوره 16 4  شماره 

صفحات  -

تاریخ انتشار 2011